Is it best to go completely Off-Grid

This depends upon your circumstances. It can be very expensive, due to the large battery bank that is required. Most people already connected to Mains usually stay connected and the solar system usually covers between 20-80% of their total consumption. If you are already Off-Grid and employing a Genset, then obviously it is better to get all your power from the PV array and only employ the Genset in case of inclement weather and emergencies.